Missed your Quality of Life question. here is my 2 cents:

送交者: 猎人于 2012-01-13, 08:07:57:

回答: How can you get something quantitative 由 cornbug 于 2012-01-12, 23:03:10:

1 QoL studies are not solid science, look at them with reservation

2 They are the least useful outcome measurement becuse they are subjective.

3 people use them when the goal of care is to improve QoL instead of cure. Case of example: late stage cancer, palliative patient,

4, Or when there are no other measurable outcome out there, e.g. Pain management. You can not measure or quantify pain despite years of effort to do that.

5, Most commonly, QoL is used as a secondary outcome measurement.

6 Don't be temped to use QoL as the primary outcome measurement. This makes your work crappy. People would suppect this might be a backup of a failed study (failed to achieve primary goal)

7 Designing non-leading QoL study is critical. Better have someone help and/or have it validated.

Just my thought. Correct me if I am wrong.

所有跟贴:

I have "change scores" as primary. Not sure Survival analysis - cornbug (105 bytes) 2012-01-13, 09:06:23 (641197)
- there is some confusion here. - 猎人 (199 bytes) 2012-01-13, 11:00:38 (641231)
  - RCT design to test the effectiveness of an intervention - cornbug (647 bytes) 2012-01-13, 11:31:10 (641240)
    - I am now getting your point - blackbox (461 bytes) 2012-01-13, 13:02:42 (641251)
      - if I remember correctly, these are all called "quality (control) study" - 猎人 (334 bytes) 2012-01-13, 13:41:08 (641256)
        
        Questionare could collect rating or scale data, - blackbox (43 bytes) 2012-01-13, 16:11:09 (641283)
        
        Questionare is OK, for the endpoint score - cornbug (68 bytes) 2012-01-13, 16:41:34 (641294)
        
        I don't understand this"...development of symptoms....." (无内容) - 猎人 (0 bytes) 2012-01-13, 19:05:55 (641310)
        
        The severity is a function of exposure time. (无内容) - cornbug (0 bytes) 2012-01-13, 23:25:16 (641333)
        
        it may more sense by reading this and the one below - blackbox (176 bytes) 2012-01-13, 18:18:30 (641306)
      - I have never been involved in a clinical trial - cornbug (929 bytes) 2012-01-13, 13:32:55 (641254)
        
        without much details re: type of intervention and outcome, - 猎人 (318 bytes) 2012-01-13, 14:43:13 (641261)
        
        ha, that is what I can say - cornbug (736 bytes) 2012-01-13, 15:05:14 (641264)
        
        currently, is there a measure to manage this condition? - 猎人 (86 bytes) 2012-01-13, 15:20:59 (641267)
        
        then your procedure and/or med is to abolish the attack - 猎人 (2058 bytes) 2012-01-13, 17:48:57 (641305)
        
        suvival analysis and QoL are additional measures - cornbug (38 bytes) 2012-01-13, 16:38:39 (641292)
        
        Every thine has a psych impact, but not serious. - cornbug (302 bytes) 2012-01-13, 16:34:05 (641290)
        
        Yes. She will do and get 5-10% of her salary. (无内容) - cornbug (0 bytes) 2012-01-13, 16:23:38 (641286)
        
        triggered externally. (无内容) - cornbug (0 bytes) 2012-01-13, 16:21:36 (641284)
        
        is the condition persistent or episodic? (无内容) - 猎人 (0 bytes) 2012-01-13, 16:07:19 (641282)
        
        still don't feel - blackbox (386 bytes) 2012-01-13, 16:04:08 (641281)
        
        what do u claim about your procedure compared with the med? - 猎人 (124 bytes) 2012-01-13, 15:54:43 (641278)
        
        Yes. Medications with temporary relief and side effects. - cornbug (20 bytes) 2012-01-13, 15:28:48 (641270)
    - few comments - 猎人 (817 bytes) 2012-01-13, 12:35:47 (641245)
      - Thanks. I have never had a cell. (无内容) - cornbug (0 bytes) 2012-01-13, 12:57:53 (641250)
        
        Oh man! you may have a loud voice and pair of sensitive ears. (无内容) - 猎人 (0 bytes) 2012-01-13, 13:12:35 (641252)
        
        I am a bug with the sixth sense. (无内容) - cornbug (0 bytes) 2012-01-13, 13:39:30 (641255)
- there is some confusion here. - 猎人 (199 bytes) 2012-01-13, 10:59:28 (641229)
good points, thanks! (无内容) - 通知 (0 bytes) 2012-01-13, 08:38:07 (641191)

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