From 1946, Yang studied with Edward Teller (1908–2003) at the University of Chicago, where he received his doctorate in 1948. He remained at the University of Chicago for a year as an assistant to Enrico Fermi. In 1949 he was invited to do his research at the Institute for Advanced Study in Princeton, New Jersey, where he began a period of fruitful collaboration with Tsung-Dao Lee. He was made a permanent member of the Institute in 1952, and full professor in 1955. In 1963, Princeton University Press published his textbook, Elementary Particles. In 1965 he moved to Stony Brook University, where he was named the Albert Einstein Professor of Physics and the first director of the newly founded Institute for Theoretical Physics. Today this institute is known as the C. N. Yang Institute for Theoretical Physics.

He retired from Stony Brook University in 1999, assuming the title Emeritus Professor. In 2010, Stony Brook University honored Yang's contributions to the university by naming its newest dormitory building C. N. Yang Hall.[4]