送交者: Latino2 于 December 13, 2004 16:45:22:
回答: 组织上早就作过结论。 由 Latino2 于 December 13, 2004 16:27:25:
反对者有权质疑，反驳，但大家都应当根据实验数据来讲话。
如果在科学的基础上争论，事情就好办了。
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Fuchs, R et al. Purification and characterization of microbially
expressed neomycin phosphotransferase II ( NPT II ) protein and
its equivalence to the plant expressed protein. Biotechnology 11
(1993), 1537-1547.
Fuchs, R et al. Safety assessment of the neomycin
phosphotransferase (NPT) II protein and its equivalence to the
plant expressed protein. Biotechnology 11 (1993), 1543-1547.
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Abstact from of the paper:
Two approaches were used to assess the safety of the NPTII protein for
human consumption using purified E. coli produced NPTII protein that was
shown to be chemically and functionally equivalent to the NPTII protein produced
in genetically engineered cotton seed, potato tubers and tomato fruit. The
NPTII protein was shown, as expected, to degrade rapidly under simulated
mammalian digestive conditions. An acute mouse gavage study confirmed that
the NPTII protein caused no deleterious effects when administered by gavage
at a cumulative target dosage of up to 5000 mg/kg of body weight. This dosage
correlates to at least a million fold safety factor relative to the average
daily consumption of potato or tomato, assuming all the potatoes or tomatoes
consumed contained the NPTII protein. These results, along with previously
published information, confirm that ingestion of genetically engineered plants
expressing the NPTII protein poses no safety concerns.