《德国肖氏手术临床试验失败》加了新翻译的一段


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送交者: 羽矢 于 2011-10-04, 23:23:13:

http://xysblogs.org/yush/archives/9349
患者群体由上运动神经元脊髓损伤(C6-Th10)患者构成,平均年龄30岁,脊髓损伤后4至288个月行腰骶神经重建术,历经平均41个月的临床随访和27个月的尿动力学随访(8名患者中的6名)。虽然观察到了有些患者膀胱和肠道功能的轻微效果,但在膀胱敏感度、导尿频率和尿失禁方面未观察到显著改变。最大膀胱容量、最大逼尿肌压力、逼尿肌-括约肌协同失调情况等尿动力学参数未观察到显著改变。患者无一达到自主排尿的基本目标。

原文:
http://www.urotoday.com/infections-1165/aua-2010-outcomes-of-intraspinal-nerve-rerouting-to-reestablish-bladder-function-in-spinal-cord-injured-patients-a-single-center-experience-session-highlights-2229825.htmlAUA%202010%20-%20Outcomes%20of%20intraspinal%20nerve%20re-routing%20to%20re-establish%20bladder%20function%20in%20spinal%20cord%20injured%20patients:%20A%20single%20center%20experience%20-%20Session%20HighlightsThu,%2010%20June%202010SAN%20FRANCISCO,%20CA%20USA%20(UroToday.com)%20-%20While%20some%20groups%20have%20reported%20on%20remarkable%20success%20with%20the%20use%20of%20lumbosacral%20nerve%20re-routing%20(LSNR)%20for%20treatment%20of%20neurogenic%20bladder%20dysfunction%20in%20patients%20with%20spina%20bifida,%20the%20investigators%20in%20this%20study%20evaluated%20eight%20adult%20spinal%20cord%20injury%20(SCI)%20patients%20who%20underwent%20LSNR%20and%20found%20profoundly%20differing%20results.The%20patient%20cohort%20included%20upper%20motor%20neuron%20SCI%20patients%20(C6-Th10)%20at%20a%20mean%20age%20of%2030%20years%20who%20underwent%20LSNR%20at%20a%20range%20of%204-288%20months%20following%20their%20SCI%20with%20a%20mean%20follow%20up%20of%2041%20months%20(clinical)%20and%2027%20months%20(urodynamic),%20the%20latter%20in%206/8%20patients.%20Although%20slight%20effects%20in%20bladder%20and%20bowel%20function%20were%20noted%20in%20some%20patients,%20no%20significant%20changes%20were%20noted%20in%20bladder%20sensation,%20catheterization%20frequency,%20or%20urinary%20incontinence.%20No%20significant%20difference%20was%20noted%20in%20urodynamic%20parameters%20including%20maximal%20bladder%20capacity,%20maximal%20detrusor%20pressure%20or%20presence%20of%20detrusor-sphincter%20dysserngia.%20No%20patients%20achieved%20the%20primary%20goal%20of%20voluntary%20micturition.The%20authors%20concluded%20that%20further%20investigation%20in%20the%20field%20of%20LSNR%20is%20necessary%20to%20establish%20the%20potential%20for%20LSNR%20in%20the%20treatment%20of%20neurogenic%20bowel%20and%20bladder%20dysfunction.Presented%20by%20Karl-Dietrich%20Sievert,%20Bastian%20Amend,%20Florian%20Roser,%20Marcos,%20Tatagiba,%20and%20Arnulf%20Stenzl%20at%20the%20American%20Urological%20Association%20(AUA)%20Annual%20Meeting%20-%20May%2029%20-%20June%203,%202010%20-%20Moscone%20Center,%20San%20Francisco,%20CA%20USAReported%20for%20UroToday%20by%20Kathleen%20C.%20Kobashi,%20MD,%20Head,%20Section%20of%20Urology%20and%20Renal%20Transplantation,%20Virginia%20Mason%20Medical%20Center,%20Seattle,%20WA,%20USA




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