解读编辑评论1,2 [ZT]


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送交者: coubert 于 2010-08-11, 11:13:22:

专家在学报上评论别人的工作,不轻易解释人家的数据和结果。这两个评论者看来是实在看不过去了,用了严厉的措辞。

Editorial Comment
John M. Park

One of the most curious findings is the discrepancy between urodynamic data and subjective voiding. One patient exhibited a decrease in capacity and an absence of reflex arc, and yet he subjectively reported improved bladder and bowel function! I could not help but speculate that his voiding after the procedure could simply be the bladder emptying via intra-abdominal pressure generation against an open bladder neck, given his preoperative stress incontinence.

你们还是专家呢,连这么显而易见的现象都看不到,在那胡扯 (I could not help but speculate)。

Xiao reported that more than 87% of 110 patients gained sensation and continence within 1 year (reference 7 in article). In comparison, the current patients undergoing the identical procedure with the help of Xiao himself only showed a modest improvement in objective urodynamic studies and subjective reporting. Unless the innovators provide a sound argument and data for the validity of the procedure, there is a great danger of its improper and rapid adaptation by patients and the medical community at large.

同样的手术程序,又有发明者帮忙,却得不到相似的结果。那个发明是扯蛋(a sound argument and data)。你们快饶了可怜的患者吧 (a great danger)。

Editorial Comment
Eric A. Kurzrock

The authors present the first North American experience with lumbar to sacral nerve rerouting for patients with spina bifida. The results from this study and previous animal and clinical studies by Xiao clearly demonstrate that nerve rerouting produces a somatic-autonomic or cutaneous/bladder reflex with stimulation of the lower extremity dermatome.1 What is also clear is that the clinical benefit of the procedure is not at all similar to previous reports.

(What is also clear is that the clinical benefit of the procedure is not at all similar to previous reports.)
要么肖胡扯,要么你们胡扯。

Although the authors did an excellent job of following the patients and characterizing their changes, the results are hard to validate without a control population going through the same rigorous surveillance regimen. In particular the improved bowel continence and minimal changes in bladder compliance may not be statistically significant. The fact that most patients were still on clean intermittent catheterization and none achieved complete urinary continence is troubling in light of the report of 87% success with 110 children with spina bifida presented by Xiao.1 One has to wonder if most of these children are not voiding volitionally or using the newly developed cutaneous reflex, and how much reinnervation has a role in this surgery. Is it possible that unilateral denervation of the S3 ventral motor nerve produced improved compliance and continence, as previously reported in numerous clinical series?[2] and [3]

(The fact that most patients were still on clean intermittent catheterization and none achieved complete urinary continence is troubling in light of the report of 87% success with 110 children with spina bifida presented by Xiao.1)
你们和肖,有一家在胡扯。

(One has to wonder if most of these children are not voiding volitionally or using the newly developed cutaneous reflex, and how much reinnervation has a role in this surgery.)
那个发射弧是扯蛋。

I congratulate the authors for taking on this challenge. I hope this study leads to a rebirth or refocus regarding neurosurgical treatments of neuropathic bowel and bladder. I strongly agree with the authors that this procedure should remain on a research protocol only.

(I congratulate the authors for taking on this challenge.)你们这帮傻瓜蛋,当初怎么会干这种没谱的事?你们还是干点正事吧 (rebirth or refocus)。




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