http://vetmed.duhs.duke.edu/documents/iacuc/pdf/policy_on_tumor_burden_in_rodents.pdfAnimals showing any of the signs below will be euthanized, unless an exemption is provided
by the Duke Attending Veterinarian or the IACUC:
a. Overall tumors volume exceeding:
i. Mice: 2000 mm3 in size (which is roughly 10% baseline body weight), or
ii. Rats: 5000 mm3 in size,
For the basis of this policy, tumors may be measured using the following formula:
TV = [(width)2 x length] / 2