http://www.mitbbs.org/article_t/Biology/31208954.htmlPosted by Elie Dolgin
[entry posted at 19th november 2008 10:26 pm gmt]
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The Journal of Experimental Biology (JEB) has issued the first retraction in
its 85 year history, the journal reported in an editorial and a retraction
notice in its December 1 issue. Although the authors' institution told JEB
their reuse of images was a careless error, the journal's editor-in-chief
called it a case of outright fraud.
The retracted paper -- published by Yideng Jiang, a molecular biologist at
Ningxia Medical College in Yinchuan, China, and his colleagues in the March
15, 2008 issue of the journal -- investigated the effects of the amino acid-
like compound homocysteine on the accumulation of cholesterol-rich
macrophages known as foam cells.
A reader alerted the journal's editor-in-chief, Hans Hoppeler, a
physiologist at the University of Bern in Switzerland, that "he had seen
similar plots in other papers," Hoppeler told The Scientist. "We tracked
that, and it was quite obvious that the same plot was used in several
publications."
Hoppeler hired an independent expert -- "a senior high level academic
working with the same technology in a very close field, but unrelated to [
jeb] or that particular area of research" -- who found that figure 6B in the
paper re-used Western blot bands that had been published the previous year
in a paper in DNA and Cell Biology.
Hoppeler said the re-used Western blots were also likely used in at least
one other paper, but did not say which. "It depends where you set the level
of evidence," he noted.
Jiang has published only three other papers, a second paper in DNA and Cell
Biology this year and two papers in Acta Biochimica et Biophysica Sinica in
May and September 2007, according to both ISI and Pubmed. Of these papers,
The Scientist found only one other that showed Western blots analyzing
similar data to that found in the retracted JEB study -- figure 7 of the
September 2007 Acta Biochimica et Biophysica Sinica paper.
JEB -- a journal with a 2007 impact factor of 2.97 according to ISI -- also
concluded that the paper contained discrepancies in the methods and
materials section, and that other data were mislabeled or inappropriately
presented.
At JEB's request, Ningxia Medical College -- the institute of six of the
paper's seven authors -- carried out its own investigation, which concluded
that the authors mistakenly reused the Western blot images due to
carelessness in computer file-naming, and that further inaccuracies stemmed
from limited English abilities, according to the published retraction.
Jiang and his coworkers confirmed the error in figure 6B and provided a
revised image to JEB. They did not admit any other problems with the paper,
said Hoppeler, who has served on JEB's editorial board since 1995 and as
editor-in-chief since 2004.
JEB also contacted the West China College of Preclinical and Forensic
Medical Sciences at Sichuan University, the institute of the paper's last
author, Shuren Wang, but never received acknowledgement of any of their
letters or E-mails.
"I think this was fraud," Hoppeler told The Scientist. But a retraction is "
as far as we can go. We have the retraction, we know the facts are on the
table, and it's clear to anybody who will ever read the paper [that this was
fraud]. Beyond that it's not [jeb's] responsibility to go any further."
DNA and Cell Biology has been alerted of the problem, but no further actions
have been taken, Hoppeler said.
Jiang's 2007 DNA and Cell Biology paper has been cited 5 times according to
ISI. Jiang's retracted JEB paper has not been cited.
JEB's publisher, the Company of Biologists, declined to comment for this
article. Jiang did not respond to E-mail requests for an interview.