谁能给个列表？
我用 He HB AND Zhejiang Univ查了一下ISI，找到11篇，列在下面：

顺便问一下，杨卫校长在接受记者采访时说：“关于投稿的事情，比如说通信作者。贺海波和吴老师提供的说法是，文章中通信作者的E-mail是吴理茂的，但贺海波联系投稿时，写的联系E-mail用的是自己的，而没有把通信作者的E-mail留上去。”杨卫这种说法在操作上可行吗？编辑不会觉得奇怪吗？

Record 1 of 11
Author(s): Liu, HR (Liu, Hao-Ran); Peng, XD (Peng, Xiang-Dong); He, HB (He, Hai-Bo); Wang, YH (Wang, Yu-Hong); Li, Y (Li, Ya); He, GX (He, Gui-Xia); Liu, YL (Liu, Ying-Lin); Li, YL (Li, Yan-Lai); Zeng, CJ (Zeng, Chun-Jiao)
Title: Antiproliferative activity of the total saponin of Solanum lyratum Thunb in Hela cells by inducing apoptosis
Source: PHARMAZIE, 63 (11): 836-842 NOV 2008
Language: English
Document Type: Article
KeyWords Plus: BCL-2 FAMILY; HL-60 CELLS; ACTIVATION; CANCER; GROWTH; RADIOTHERAPY; CASPASES; PROTEINS; PROTEASE; RECEPTOR
Abstract: Total saponin of Solanum lyratum Thunb (TSSLT), a species of natural biologically active substances isolated from Solanum lyratum Thunb, possesses various bioactivities. It has been proposed that the induction of apoptosis may be the basis of its antitumor activity. However, the molecular mechanism underlying the total saponin-induced apoptotic process remains unknown. In the present study, we describe the anti-proliferative effect of TSSLT on human cervical cancer cells (Hela). The TSSLT induced apoptosis of Hela in a time-dependent manner with an IC50 for cell viability of 6 mu g/ml. The TSSLT-induced cell death was characterized by changes in cell morphology, DNA fragmentation, activation of caspase-like activities, poly (ADP-ribose) polymerase (PARP) cleavage and release of cytochrome c (cyt c) into cytosol. TSSLT activated various caspases such as caspase-3, -8, and -9 (like) activities but not caspase-1 like activity. The cell death was completely prevented by the pan caspase inhibitor benzyloxy carbonyl-Val-Ala-Asp- fluoromethyl-ketone (Z-VAD-FMK). More than 80% cell survival was observed in the presence of a caspase-3 inhibitor. In addition, treatment with TSSLT induced the increase of Bax:Bcl-2 ratio in Hela cells. These results suggest that the induction of apoptosis by TSSLT involves multiple pathways antigen including death receptor and mitochondrial pathway and strongly suggest that the mitochondrial pathway was mediated by low expression of Bcl-2 and upregulation of Bax, release of cyt c and subsequent activation of caspase-3 followed by down stream events leading to apoptotic cell death.
Addresses: [he, hai-bo] Zhejiang Univ, Inst Chinese Herb Med, Coll Pharmaceut Sci, Hangzhou 310058, Zhejiang, Peoples R China; [liu, hao-ran; liu, ying-lin; li, yan-lai; zeng, chun-jiao] Hunan Univ, Dept Pharmacol, Coll Chem & Chem Engn, Changsha 410082, Hunan, Peoples R China; [peng, xiang-dong] Cent S Univ, Xiangya Hosp 3, Dept Pharm, Changsha, Hunan, Peoples R China; [he, gui-xia] Hunan Univ TCM, Coll Pharm, Dept Nat Pharmaceut Chem, Changsha, Hunan, Peoples R China
Reprint Address: He, HB, Zhejiang Univ, Inst Chinese Herb Med, Coll Pharmaceut Sci, Hangzhou 310058, Zhejiang, Peoples R China.
E-mail Address: hehabo@126.com
Cited Reference Count: 30
Times Cited: 0
Publisher: GOVI-VERLAG PHARMAZEUTISCHER VERLAG GMBH
Publisher Address: PHARMAZEUTISCCARL MANNICH STR 26, D-65760 ESCHBORN, GERMANY
ISSN: 0031-7144
DOI: 10.1691/ph.2008.8607
29-char Source Abbrev.: PHARMAZIE
ISO Source Abbrev.: Pharmazie
Source Item Page Count: 7
Subject Category: Chemistry, Medicinal; Chemistry, Multidisciplinary; Pharmacology & Pharmacy
ISI Document Delivery No.: 373LJ

Record 2 of 11
Author(s): He, HB (He, Hai-Bo); Yang, XZ (Yang, Xian-Zhe); Shi, MQ (Shi, Meng-Qiong); Zeng, XW (Zeng, Xiao-Wei); Wu, LM (Wu, Li-Mao); Li, LD (Li, Lian-Da)
Title: Comparison of cardioprotective effects of salvianolic acid B and benazepril on large myocardial infarction in rats
Source: PHARMACOLOGICAL REPORTS, 60 (3): 369-381 MAY-JUN 2008
Language: English
Document Type: Article
Author Keywords: salvianolic acid B; benazepril; large myocardial infarction; heart function; blood viscosity; angiogenesis; infarct size; ventricular remodeling
KeyWords Plus: LEFT-VENTRICULAR DYSFUNCTION; ENDOTHELIAL GROWTH-FACTOR; IN-VITRO; NAD(P)H OXIDASE; HEART-FAILURE; NADPH OXIDASE; UP-REGULATION; ANGIOGENESIS; MILTIORRHIZA; EXPRESSION
Abstract: In the present study, we compared cardioprotective effects of salvianolic acid B (Sal B) and the angiotension-converting enzyme inhibitor, benazepril, in rats with large myocardial infarction (MI). The large MI was produced by coronary artery ligation for 4 weeks in rats. The rats were divided into the following groups: sham operation; MI; MI + Sal B (100 mg/kg by a gavage, once a day for 4 weeks) and MI + benazepril (I mg/kg by a gavage, once a day for 4 weeks). Echocardiogram, hemodynamic and hemorheological changes, angiogenesis, infarct size and cardiac remodeling, as well as messenger ribonucleic acid (mRNA) of vascular endothelium growth factor (VEGF) were measured. The following similar effects were observed in MI rats treated with Sal B and benazepril: (1) a marked improvement of echocardiographic, hemodynamic and hemorheological parameters, (2) significant reduction of infarct size, (3) significantly attenuated heart hypertrophy, left ventricular (LV) dilatation and fibrosis. The unique effects of Sal B were: angiogenesis and augmented VEGF expression in the border and remote noninfarcted LV area. These results suggest that Sal B and benazepril exerted beneficial cardioprotective effects. However, Sal B enforced some different modality than benazepril, which might improve myocardial microcirculation by augmenting VEGF expression and promoting angiogenesis besides similar effects to benazepril.
Addresses: [he, hai-bo; yang, xian-zhe; zeng, xiao-wei; wu, li-mao; li, lian-da] Zhejiang Univ, Inst Chinese Herbal Med, Coll Pharmaceut Sci, Hangzhou 310058, Zhejiang, Peoples R China; [shi, meng-qiong] Ctr Med Sci Anal, Hangzhou 310053, Zhejiang, Peoples R China
Reprint Address: Wu, LM, Zhejiang Univ, Inst Chinese Herbal Med, Coll Pharmaceut Sci, Hangzhou 310058, Zhejiang, Peoples R China.
E-mail Address: wulimao@zju.edu.cn
Funding Acknowledgement:
Funding Agency     Grant Number
National Postdoctor Science Foundation of China     
20070411201
National Natural Science Foundation of China     
30500661
National Important Basic Development Plan of China     
2005CB523405

This study was supported by a project from National Postdoctor Science Foundation of China (No. 20070411201), a common project from National Natural Science Foundation of China (No. 30500661) and a grant of National Important Basic Development Plan of China (also called 973 project, No Professor Dr Yu-Iing Ma (Research Fellow, School of Pharmacy, University of Reading, GB) provided assistance with the composition and English styling of the paper.
Cited Reference Count: 36
Times Cited: 0
Publisher: POLISH ACAD SCIENCES INST PHARMACOLOGY
Publisher Address: SMETNA 12, 31-343 KRAKOW, POLAND
ISSN: 1734-1140
29-char Source Abbrev.: PHARMACOL REP
ISO Source Abbrev.: Pharmacol. Rep.
Source Item Page Count: 13
Subject Category: Pharmacology & Pharmacy
ISI Document Delivery No.: 353AB

Record 3 of 11
Author(s): He, HB (He, Haibo); Liu, QJ (Liu, Qiuju); Shi, MQ (Shi, Mengqiong); Zeng, XW (Zeng, Xiaowei); Yang, J (Yang, Jun); Wu, LM (Wu, Limao); Li, LD (Li, Lianda)
Title: Cardioprotective effects of hydroxysafflor yellow A on diabetic cardiac insufficiency attributed to up-regulation of the expression of intracellular calcium handling proteins of sarcoplasmic reticulum in rats
Source: PHYTOTHERAPY RESEARCH, 22 (8): 1107-1114 AUG 2008
Language: English
Document Type: Article
Author Keywords: hydroxysafflor yellow A; diabetic cardiomyopathy; calcium handling proteins; endothelin system; reactive oxygen species pathway
KeyWords Plus: HEART-FAILURE; OXIDATIVE STRESS; NITRIC-OXIDE; CONTRACTILE DYSFUNCTION; RYANODINE RECEPTOR; CARDIOMYOPATHY; ENDOTHELIN; RELEASE; PATHWAY; OVEREXPRESSION
Abstract: Depressed sarcoplasmic reticulum (SR) Ca2+-ATPase (SERCA2a) and Ca2+-release channels (ryanodine receptor RyR2) are involved in diabetic cardiomyopathy, however, the implication of intracellular calcium handling proteins in SR is undefined. It was hypothesized that the down-regulation of the intracellular calcium handling proteins of SR is closely related to an up-regulated endothelin (ET) system. Hydroxysafflor yellow A (HSYA) is expected to ameliorate cardiac insufficiency which is mediated by the depressed intracellular calcium handling system in diabetic rat heart. Diabetes was produced in male rats 8 weeks after an injection of streptozotocin (60 mg/kg i.p.) and HSYA was administered (100 mg/kg) by gavage in the last 4 weeks. Hemodynamic and echo cardiographic changes, cardiac calcium handling proteins, serum biochemistry, ET system and redox were measured. The compromised cardiac function in diabetic rats was accompanied by a significant down-regulation of the expression of RyR2, FKBP12.6 as well as SERCA2a and PLB. These were closely linked with oxidative stress, an increased ET-1 and up-regulation of ECE, PropreET-1 and iNOS mRNA in diabetic cardiomyopathy. After a 4 week treatment with HSYA, all abnormalities were reversed significantly. In conclusion, diabetic cardiomyopathy was correlated with an abnormal expression of calcium handing proteins in SR and an activated ET-ROS (reactive oxygen species) system in the diabetic affected myocardium. HSYA significantly improved the cardiac function and down-regulated the ET system and ROS pathway, resulting in a reversal of the abnormalities of expression of calcium handing proteins and the cardiac performance in diabetic cardiomyopathy. Copyright (C) 2008 John Wiley & Sons, Ltd.
Addresses: [he, haibo; zeng, xiaowei; yang, jun; wu, limao] Zhejiang Univ, Coll Pharmaceut Sci, Inst Chinese Herbal Med, Hangzhou 310058, Zhejiang, Peoples R China; [liu, qiuju] Ezhou Third People Hosp, Ezhou, Hubei, Peoples R China; [shi, mengqiong] Ctr Med Sci Anal, Hangzhou, Zhejiang, Peoples R China
Reprint Address: Wu, LM, Zhejiang Univ, Coll Pharmaceut Sci, Inst Chinese Herbal Med, Zijingang Campus, Hangzhou 310058, Zhejiang, Peoples R China.
E-mail Address: wulimao@zju.edu.cn
Funding Acknowledgement:
Funding Agency     Grant Number
National Natural Science Foundation of China     
30500661
National Important Basic Development Plan of China     
2005CB523405
Key Projects of Zhejiang Province     
2004C13022

The authors thank Dr Yuling Ma, University of Reading, UK, a visiting Professor in our Department, for providing assistance with the composition and English styling of the paper.

This project was supported by the National Natural Science Foundation of China (No: 30500661), the National Important Basic Development Plan of China (also called 973 project. No: 2005CB523405) and the Technology Foundation for Key Projects of Zhejiang Province (No: 2004C13022).
Cited Reference Count: 45
Times Cited: 0
Publisher: JOHN WILEY & SONS LTD
Publisher Address: THE ATRIUM, SOUTHERN GATE, CHICHESTER PO19 8SQ, W SUSSEX, ENGLAND
ISSN: 0951-418X
DOI: 10.1002/ptr.2468
29-char Source Abbrev.: PHYTOTHER RES
ISO Source Abbrev.: Phytother. Res.
Source Item Page Count: 8
Subject Category: Chemistry, Medicinal; Pharmacology & Pharmacy
ISI Document Delivery No.: 345IH

Record 4 of 11
Author(s): He, HB (He, Haibo); Shi, MQ (Shi, Mengqiong); Zeng, XW (Zeng, Xiaowei); Yang, XZ (Yang, Xianzhe); Yang, J (Yang, Jun); Wu, LM (Wu, Limao); Li, LD (Li, Lianda)
Title: Decreased FKBP12.6 expression and enhanced endothelin receptor signaling associated with arrhymogenesis in myocardial infarction rats
Source: PHYTOTHERAPY RESEARCH, 22 (8): 1115-1124 AUG 2008
Language: English
Document Type: Article
Author Keywords: ryanodine receptor 2 (RyR2); FKBP12.6; endothelin-1; calcium transients; salvianolic acid B; propranolol
KeyWords Plus: POLYMORPHIC VENTRICULAR-TACHYCARDIA; CHANNEL RYANODINE RECEPTOR; SUDDEN CARDIAC DEATH; LONG-QT SYNDROME; HEART-FAILURE; SEPTIC SHOCK; CA2+ LEAK; CARDIOMYOPATHY; PHOSPHORYLATION; REPERFUSION
Abstract: An increased propensity towards cardiac arrhythmias and aggravated heart function is observed in myocardial infarction (MI), the development of which is associated with the calcium handling system in the myocardium. It was hypothesized that the abnormal changes in the MI model may be a consequence of the abnormal expression and function of the RyR2-FKBP12.6 channel complex and that these abnormalities may be related to an over-activated endothelin (ET) system. Salvianolic acid B is expected to suppress life-threatening arrhythmias and to restore the abnormality of the RyR2-FKBP12.6 complex in rats. MI was produced by ligating the coronary artery for 4 weeks. Salvianolic acid B (100 mg/kg/day, p.o. for 4 weeks) was administered to rats 0.5 h before surgery. Measurements of cardiac arrhythmias, cardiac function, calcium transient, cardiac calcium release channel handling proteins and the endothelin system were conducted. The aggravated arrhythmia and compromised cardiac function in MI rats was accompanied by elevated diastolic Ca2+ levels in the cytosol and a significant down-regulation of expression of RyR2-FKBP12.6. These were closely linked with an over-activated ET pathway in the myocardium. After a 4-week treatment with salvianolic acid B, all abnormalities were reversed significantly. Salvianolic acid B was capable of normalizing FKBP12.6 expression levels and decreasing the propensity towards arrhythmias by attenuating the tip-regulated ET pathway. Copyright (C) 2008 John Wiley & Sons, Ltd.
Addresses: [he, haibo; zeng, xiaowei; yang, xianzhe; yang, jun; wu, limao; li, lianda] Zhejiang Univ, Coll Pharmaceut Sci, Inst Chinese Herb Sci, Hangzhou 310058, Zhejiang, Peoples R China; [shi, mengqiong] Ctr Med Sci Anal, Hangzhou 310053, Zhejiang, Peoples R China
Reprint Address: Wu, LM, Zhejiang Univ, Coll Pharmaceut Sci, Inst Chinese Herb Sci, Hangzhou 310058, Zhejiang, Peoples R China.
E-mail Address: wulimao@zju.edu.cn
Funding Acknowledgement:
Funding Agency     Grant Number
National Natural Science Foundation of China     
30500661
National Important Basic Development Plan of China     
2005CB523405
Zhejiang Provincial Science and Technology     
200403022
2005C13027
Zhejiang Department of Education     
20061328
Zhejiang Bureau of Traditional Chinese Medicine     
2006Z015

The study was supported by a common project from National Natural Science Foundation of China (No: 30500661), a grant from National Important Basic Development Plan of China (also called 973 project, No: 2005CB523405) and grants from Mega-projects of Zhejiang Provincial Science and Technology, (No. 200403022, 2005C13027), a grant from Zhejiang Department of Education (No. 20061328), a grant from Zhejiang Bureau of Traditional Chinese Medicine (No, 2006Z015). Dr Yuling Ma, University of Reading, UK a visiting Professor in our Department, provided assistance with the composition and English styling of the paper.
Cited Reference Count: 44
Times Cited: 2
Publisher: JOHN WILEY & SONS LTD
Publisher Address: THE ATRIUM, SOUTHERN GATE, CHICHESTER PO19 8SQ, W SUSSEX, ENGLAND
ISSN: 0951-418X
DOI: 10.1002/ptr.2470
29-char Source Abbrev.: PHYTOTHER RES
ISO Source Abbrev.: Phytother. Res.
Source Item Page Count: 10
Subject Category: Chemistry, Medicinal; Pharmacology & Pharmacy
ISI Document Delivery No.: 345IH

Record 5 of 11
Author(s): Zeng, XW (Zeng, Xiaowei); He, HB (He, Haibo); Yang, J (Yang, Jun); Yang, XZ (Yang, Xianzhe); Wu, LM (Wu, Limao); Yu, J (Yu, Jun); Li, LD (Li, Lianda)
Title: Temporal effect of Guanxin No. 2 on cardiac function, blood viscosity and angiogenesis in rats after long-term occlusion of the left anterior descending coronary artery
Source: JOURNAL OF ETHNOPHARMACOLOGY, 118 (3): 485-494 AUG 13 2008
Language: English
Document Type: Article
Author Keywords: cardiac infarction; Guanxin No. 2 decoction (GX II); angiogenesis; VEGF
KeyWords Plus: ENDOTHELIAL GROWTH-FACTOR; INDUCED MYOCARDIAL-INFARCTION; ANTIOXIDANT STATUS; NADPH OXIDASE; ISCHEMIA; DISEASE; THERAPY; TRIAL
Abstract: Aim: Cardiac infarction is one of the main causes of death in both developing and developed countries over past decades. Currently available approaches for treating patients with this disease are not satisfactory. Traditional Chinese medicines have been increasingly paid attention to. The aim of this study was to characterize the dynamic protective effects of Guanxin No. 2 decoction (GX II) on cardiac dysfunction combined with the blood viscosity and myocardial hypertrophy parameters in myocardial infarction (MI) rats.
Methods: Male Sprague-Dawley rats (180-200g) were randomly divided into three groups: sham-operated, coronary artery ligation (CAL), and CAL plus GX II (GX II, 10.0 g raw materials/kg/d, bid, p.o.). The experiment was carried out at 4 time points as the 3rd, 7th, 14th, and 28th day after ligation.
Result: It was found that on the one hand, GX II could significantly improve the heart function, and remarkably decrease infarct size and inhibit ventricular remodeling. On the other hand. GX II showed some unique effects such as angiogenesis which was induced in the left ventricular tissue. This result was consistent with the finding of an augmented vascular endothelial growth factor (VEGF) expression in this area.
Conclusions: The studies demonstrated that GX II exerted extensively beneficial cardioprotective effect on CAL rats, it might stimulate angiogenesis of ischemic region to compensate blood supply to the heart via upregulated VEGF expression. (c) 2008 Elsevier Ireland Ltd. All rights reserved.
Addresses: [zeng, xiaowei; he, haibo; yang, jun; yang, xianzhe; wu, limao; li, lianda] Zhejiang Univ, Inst Chinese Herb Med, Coll Pharmaceut Sci, Hangzhou 310058, Zhejiang, Peoples R China; [zeng, xiaowei; yu, jun] Zhejiang Univ, Coll Life Sci, Hangzhou 310058, Zhejiang, Peoples R China; [zeng, xiaowei; yu, jun] Zhejiang Univ, James D Watson Inst Genome Sci, Hangzhou 310058, Zhejiang, Peoples R China
Reprint Address: Wu, LM, Zhejiang Univ, Inst Chinese Herb Med, Coll Pharmaceut Sci, Hangzhou 310058, Zhejiang, Peoples R China.
E-mail Address: wulimao@zju.edu.cn; junyu@genomics.org.cn
Funding Acknowledgement:
Funding Agency     Grant Number
National Important Basic Development Plan of China     
2005CB523405
Zhejiang Provincial Science and Technology     
2004C13022
2005C13027
Zhejiang Department of Education     
20061328
Zhejiang Bureau of Traditional Chinese Medicine     
2006Z015
National Science Foundation of China     
30500661

This study was supported by a grant from National Important Basic Development Plan of China (also called 973 project, No: 2005CB523405), grants of Mega-projects of Zhejiang Provincial Science and Technology (Nos. 2004C13022, 2005C13027), a grant of Zhejiang Department of Education (No. 20061328), a grant of Zhejiang Bureau of Traditional Chinese Medicine (No. 2006Z015), and a grant of National Science Foundation of China (No. 30500661).
Cited Reference Count: 31
Times Cited: 0
Publisher: ELSEVIER IRELAND LTD
Publisher Address: ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND
ISSN: 0378-8741
DOI: 10.1016/j.jep.2008.05.017
29-char Source Abbrev.: J ETHNOPHARMACOL
ISO Source Abbrev.: J. Ethnopharmacol.
Source Item Page Count: 10
Subject Category: Plant Sciences; Chemistry, Medicinal; Integrative & Complementary Medicine; Pharmacology & Pharmacy
ISI Document Delivery No.: 342NK

Record 6 of 11
Author(s): He, HB (He, Haibo); Shi, MQ (Shi, Mengqiong); Yang, XZ (Yang, Xianzhe); Zeng, XW (Zeng, Xiaowei); Wu, LM (Wu, Limao); Li, LD (Li, Lianda)
Title: Comparison of cardioprotective effects using salvianolic acid B and benazepril for the treatment of chronic myocardial infarction in rats
Source: NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 378 (3): 311-322 SEP 2008
Language: English
Document Type: Article
Author Keywords: angiogenesis; benazepril; blood viscosity; chronic myocardial infarction; heart function; infarct size; salvianolic acid B; ventricular remodeling
KeyWords Plus: ENDOTHELIAL GROWTH-FACTOR; LEFT-VENTRICULAR DYSFUNCTION; IN-VITRO ANGIOGENESIS; NAD(P)H OXIDASE; GENE-EXPRESSION; HEART-FAILURE; NADPH OXIDASE; UP-REGULATION; MILTIORRHIZA; ISCHEMIA
Abstract: The aim of this study was to compare the cardioprotective effects of salvianolic acid B (Sal B) and the angiotension-converting enzyme inhibitor, benazepril, in rats with chronic myocardial infarction (MI) that resulted from a coronary artery ligation for 4 weeks. The rats were divided into four groups: those undergoing a sham operation; a MI group; a MI+SalB group (100 mg/kg by a gavage, once a day for 4 weeks); a MI+benazepril group (10 mg/kg by a gavage, once a day for 4 weeks). The following parameters were measured: echocardiographic, hemodynamic and hemorheological changes, angiogenesis, infarct size and cardiac remodeling and the messenger ribonucleic acid (mRNA) of vascular endothelium growth factor (VEGF). Rats treated with SalB or benazepril manifested the following: (1) marked improvements in echocardiographic, hemodynamic and hemorheological parameters; (2) significant reduction of infarct size; (3) significantly attenuated heart, kidney and lung hypertrophies, left ventricular (LV) dilatation and fibrosis. The unique effects of SalB were angiogenesis and augmented VEGF expression in the border and remote noninfarcted left ventricular area. These results suggest that both SalB and benazepril exerted beneficial cardioprotective effects in our experimental system, but that the modality of Sal B was different from that of benazepril. The additional beneficial effects of Sal B relative to benazpril, augmenting VEGF expression and promoting angiogenesis, may result in improved myocardial microcirculation.
Addresses: [he, haibo; yang, xianzhe; zeng, xiaowei; wu, limao; li, lianda] Zhejiang Univ, Inst Chinese Herbal Med, Coll Pharmaceut, Hangzhou 310058, Zhejiang, Peoples R China; [shi, mengqiong] Ctr Med Sci Anal, Hangzhou, Zhejiang, Peoples R China
Reprint Address: Wu, LM, Zhejiang Univ, Inst Chinese Herbal Med, Coll Pharmaceut, Zijingang Campus, Hangzhou 310058, Zhejiang, Peoples R China.
E-mail Address: wulimao@zju.edu.cn
Funding Acknowledgement:
Funding Agency     Grant Number
National Postdoctor Science Foundation of China     
20070411201
National Natural Science Foundation of China     
30500661
National Important Basic Development Plan of China     
2005CB523405

This study was supported by a project from the National Postdoctor Science Foundation of China (No: 20070411201), a common project of Chinese Medica Science Foundation of Zhejiang Province, a common project from National Natural Science Foundation of China (No: 30500661) and a grant of National Important Basic Development Plan of China (also called 973 project, No: 2005CB523405). Professor Dr. Yuling Ma (Research Fellow, School of Pharmacy, University of Reading, GB) provided assistance with the composition and English styling of the paper.
Cited Reference Count: 45
Times Cited: 0
Publisher: SPRINGER
Publisher Address: 233 SPRING ST, NEW YORK, NY 10013 USA
ISSN: 0028-1298
DOI: 10.1007/s00210-008-0287-6
29-char Source Abbrev.: NAUNYN-SCHMIED ARCH PHARMACOL
ISO Source Abbrev.: Naunyn-Schmiedebergs Arch. Pharmacol.
Source Item Page Count: 12
Subject Category: Pharmacology & Pharmacy
ISI Document Delivery No.: 339KR

Record 7 of 11
Author(s): He, HB (He, Haibo); Shi, MQ (Shi, Mengqiong); Yang, J (Yang, Jun); Zeng, XW (Zeng, Xiaowei); Qiao, HX (Qiao, Hongxiang); Wu, LM (Wu, Limao); Li, LD (Li, Lianda)
Title: The correlation between angiogenesis and abnormal expression of SERCA2a, phospholamban and the endothelin pathway in heart failure, and improvement by puerarin
Source: PHYTOTHERAPY RESEARCH, 22 (7): 948-956 JUL 2008
Language: English
Document Type: Article
Author Keywords: angiogenesis pathway; heart failure; ET-ROS pathway; SERCA2a; PLB; puerarin
KeyWords Plus: LEFT-VENTRICULAR DYSFUNCTION; ACUTE MYOCARDIAL-INFARCTION; RECEPTOR ANTAGONIST; GROWTH-FACTOR; ETB-RECEPTOR; RATS; THERAPY; REPOLARIZATION; STIMULATION; ISCHEMIA
Abstract: Emerging evidence indicates that angiogenesis may be a potential new target in treating heart failure (HF). It was hypothesized that a lack of angiogenesis would correlate with an abnormal expression of sarco/endoplasmic reticulum ATPase 2a (SERCA2a) and phospholamban (PLB), and the activated endothelin (ET) pathway and oxidative stress in HIT. If this is the case, such normal changes could be reversed by puerarin. HIF was produced by coronary artery ligation for 4 weeks in rats. The rats were divided into three groups: sham, HIF untreated and HIT + puerarin (120 mg/kg per day, i.p.). Hemodynamic and echocardiographic changes, angiogenesis, cardiac morphology, serum biochemistry, mRNA and proteins of the angiogenesis pathway, the ET pathway and redox were measured. In the HF rats, hemodynarnic and echocardiographic abnormalities, cardiac remodeling and histological changes with features of cardiac failure were associated with a lack of the angiogenesis pathway, accompanied by oxidative stress, an up-regulated ET pathway and abnormal SERCA2a and PLB expressions in HF rats. Puerarin significantly promoted angiogenesis and reversed the above changes. In conclusion, the absence of the angiogenesis pathway correlated with abnormal expression of SERCA2a and PLB and an activated ET-ROS (reactive oxygen species) system in the affected myocardium. Puerarin promoted the angiogenesis pathway, improved myocardial microcirculation and down-regulated the ET system, resulting in a reversal of the abnormalities of expression of SERCA2a and PLB, and the cardiac performance in HF. Copyright (c) 2008 John Wiley & Sons, Ltd.
Addresses: [he, haibo; yang, jun; zeng, xiaowei; qiao, hongxiang; wu, limao; li, lianda] Zhejiang Univ, Coll Pharmaceut Sci, Inst Chinese Herbal Med, Hangzhou 310058, Peoples R China; [shi, mengqiong] Ctr Med Sci Anal, Dahe Clique, Hangzhou, Peoples R China
Reprint Address: Wu, LM, Zhejiang Univ, Coll Pharmaceut Sci, Inst Chinese Herbal Med, Zijiangang Campus, Hangzhou 310058, Peoples R China.
E-mail Address: wulimao@zju.edu.cn
Cited Reference Count: 36
Times Cited: 0
Publisher: JOHN WILEY & SONS LTD
Publisher Address: THE ATRIUM, SOUTHERN GATE, CHICHESTER PO19 8SQ, W SUSSEX, ENGLAND
ISSN: 0951-418X
DOI: 10.1002/ptr.2437
29-char Source Abbrev.: PHYTOTHER RES
ISO Source Abbrev.: Phytother. Res.
Source Item Page Count: 9
Subject Category: Chemistry, Medicinal; Pharmacology & Pharmacy
ISI Document Delivery No.: 332AO

Record 8 of 11
Author(s): He, HB (He, Haibo); Shi, MQ (Shi, Mengqiong); Zeng, XW (Zeng, Xiaowei); Yang, J (Yang, Jun); Li, YK (Li, Yikui); Wu, LM (Wu, Limao); Li, LD (Li, Lianda)
Title: Cardioprotective effect of salvianolic acid B on large myocardial infarction mediated by reversing upregulation of leptin, endothelin pathways, and abnormal expression of SERCA2a, phospholamban in rats
Source: JOURNAL OF ETHNOPHARMACOLOGY, 118 (1): 35-45 JUN 19 2008
Language: English
Document Type: Article
Author Keywords: salvianolic acid B; leptin; ET-ROS pathway; SERCA2a; PLB; cardiac failure
KeyWords Plus: HEPATIC STELLATE CELLS; IN-VITRO ANGIOGENESIS; CHRONIC HEART-FAILURE; VENTRICULAR MYOCYTES; NADPH OXIDASE; PLASMA LEPTIN; CONTRACTILE FUNCTION; ETB-RECEPTOR; MILTIORRHIZA; HYPERTROPHY
Abstract: Aim: To study the cardioprotective effect of salvianolic acid B (Sal B) on cardiac dysfunction. We hypothesized that hyperleptinemia may correlate with abnormal expression of sarco/endoplasmic reticulum ATPase 2a (SERCA2a), phospholamban (PLB) and endothelin-reactive oxygen species (ET-ROS) pathways in rats with large myocardial infarction (MI).
Methods: Large MI was produced by coronary artery ligation for 4 weeks in rats. The rats were divided into four groups: sham, MI, MI+1-Sal B (50 mg/(kgd)), p.o. for 4 weeks), and MI+h-Sal B (100 mg/(kg d)), p.o. for 4 weeks).
Results: In MI rats, hemodynamic and echocardiographic abnormalities, cardiac remodeling, and histological changes with features of cardiac failure were associated with hyperleptinemia accompanied by oxidative stress and upregulated OB-Rb, ET pathway mRNA expression and downregulated SERCA2a and PLB mRNA and protein expressions in the myocardium.
Conclusions: The studies demonstrated that an activated leptin pathway correlated with abnormal expression of SERCA2a, PLB and an activated ET-RCS system in the affected myocardium. Sal B exerts beneficial actions on cardiac function in rats with large MI, mainly suppressing upregulation of leptin and ET pathways and oxidative stress, and recovering the normal expressions of SERCA2a and PLB in myocardium. (C) 2008 Elsevier Ireland Ltd. All rights reserved.
Addresses: [he, haibo; zeng, xiaowei; yang, jun; wu, limao; li, lianda] Zhejiang Univ, Coll Pharmaceut Sci, Inst Chinese Herbal Med, Hangzhou 310058, Peoples R China; [shi, mengqiong] Dahe Clique, Ctr Med Sci Anal, Hangzhou 310053, Peoples R China; [li, yikui] Xiyuan Hosp, China Acad Tradit Chinese Med, Beijing 100091, Peoples R China
Reprint Address: Wu, LM, Zhejiang Univ, Coll Pharmaceut Sci, Inst Chinese Herbal Med, Zijingang Campus, Hangzhou 310058, Peoples R China.
E-mail Address: wulimao@zju.edu.cn
Cited Reference Count: 45
Times Cited: 0
Publisher: ELSEVIER IRELAND LTD
Publisher Address: ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND
ISSN: 0378-8741
DOI: 10.1016/j.jep.2008.03.006
29-char Source Abbrev.: J ETHNOPHARMACOL
ISO Source Abbrev.: J. Ethnopharmacol.
Source Item Page Count: 11
Subject Category: Plant Sciences; Chemistry, Medicinal; Integrative & Complementary Medicine; Pharmacology & Pharmacy
ISI Document Delivery No.: 321VW

Record 9 of 11
Author(s): He, HB (He, Haibo); Yang, XZ (Yang, Xianzhe); Shi, MQ (Shi, Mengqiong); Zeng, XW (Zeng, Xiaowei); Yang, J (Yang, Jun); Wu, LM (Wu, Limao); Li, LD (Li, Lianda)
Title: Protective effects of hydroxysafflor yellow A on acute and chronic congestive cardiac failure mediated by reducing ET-1, NOS and oxidative stress in rats
Source: JOURNAL OF PHARMACY AND PHARMACOLOGY, 60 (1): 115-123 JAN 2008
Language: English
Document Type: Article
KeyWords Plus: NITRIC-OXIDE SYNTHASE; LEFT-VENTRICULAR DYSFUNCTION; HEART-FAILURE; MYOCARDIAL-INFARCTION; GENE-EXPRESSION; PROBUCOL
Abstract: The present study was conducted to investigate whether hydroxysafflor yellow A (HSYA) has a protective effect on acute and chronic heart failure (AHF/CHF) induced by ligation of the left anterior descending coronary artery for 3 h and 8 weeks, respectively. The rats were divided into the following groups: sham operation, coronary artery ligation (CAL), CAL+HSYA (100mg kg(-1) by gavage) and CAL+diltiazem (20mg kg(-1) by gavage). In the AHF model, heart function, as determined by haemodynamic studies and echocardiography, was improved significantly by pretreatment with HSYA or diltiazem. Significant reductions in elevated serum creatine phosphokinase, lactate dehydrogenase, malondialdehyde (MDA), glutamic oxalacetic transaminase, glutamic pyruvic transaminase and blood viscosity were observed, and the activity of serum superoxide dismutase (SOD) was enhanced (all P<0.01). In the CHF model, HSYA and diltiazem restored abnormal heart function, and completely suppressed the elevated plasma atrial natriuretic polypeptide (ANP) and endothelin-1 (ET-1), serum and left-ventricular tissue inducible nitric oxide (NO) synthase (iNOS), NO and MDA, and improved the decrease in SOD. HSYA and diltiazem improved cardiac performance in AHF and reduced cardiac remodelling in CHF by reducing tissue weight indices: left ventricular weight/body weight (BW), right ventricular weight/BW, kidney weight/BW and lung weight/BW, and attenuating increases in infarct size, inner diameter of the left ventricle and collagen volume fraction in non-infarcted areas, and the decrease in mean wall thickness of infarcted myocardium. These results suggest that HSYA exerted beneficial actions in cardiac performance in models of both AHF and CHF, mainly by suppressing ET-1, iNOS and oxidative stress in infarcted tissue.
Addresses: [he, haibo; yang, xianzhe; zeng, xiaowei; yang, jun; wu, limao; li, lianda] Zhejiang Univ, Inst Chinese Herb Med, Coll Pharmaceut Sci, Hangzhou 310058, Zhejiang, Peoples R China; [shi, mengqiong] Ctr Med Sci Anal, Hangzhou 310053, Zhejiang, Peoples R China
Reprint Address: Wu, LM, Zhejiang Univ, Inst Chinese Herb Med, Coll Pharmaceut Sci, Hangzhou 310058, Zhejiang, Peoples R China.
E-mail Address: wulimao@zju.edu.cn
Cited Reference Count: 46
Times Cited: 2
Publisher: PHARMACEUTICAL PRESS-ROYAL PHARMACEUTICAL SOC GREAT BRITIAN
Publisher Address: 1 LAMBETH HIGH ST, LONDON SE1 7JN, ENGLAND
ISSN: 0022-3573
DOI: 10.1211/jpp.60.1.0015
29-char Source Abbrev.: J PHARM PHARMACOL
ISO Source Abbrev.: J. Pharm. Pharmacol.
Source Item Page Count: 9
Subject Category: Pharmacology & Pharmacy
ISI Document Delivery No.: 262ML

Record 10 of 11
Author(s): He, HB (He, Haibo); Yang, XZ (Yang, Xianzhe); Zeng, XW (Zeng, Xiaowei); Shi, MQ (Shi, Mengqiong); Yang, J (Yang, Jun); Wu, LM (Wu, Limao); Li, LA (Li, Lianda)
Title: Protective effect of Liuwei Dihuang decoction on early diabetic nephropathy induced by streptozotocin via modulating ET-ROS axis and matrix metalloproteinase activity in rats
Source: JOURNAL OF PHARMACY AND PHARMACOLOGY, 59 (9): 1297-1305 SEP 2007
Language: English
Document Type: Article
KeyWords Plus: NITRIC-OXIDE; EXTRACELLULAR-MATRIX; RECEPTOR ANTAGONIST; ENDOTHELIN-ETA; EARLY MARKER; MELLITUS; COMPLICATIONS; HYPERTROPHY; GLOMERULI; PATHWAY
Abstract: We aimed to investigate the effects of Liuwei Dihuang decoction (LW) on the endothelin-1-reactive oxidative species (ET-ROS) system and matrix metalloproteinases (MMPs) in the early diabetic nephropathy induced by streptozotocin (STZ) in rats. Rats were divided into six groups as follows: the control group, the untreated model group, the treated groups with the LW (5, 10 and 15 g kg(-1), p.o.) and the aminoguanidine-treated group (100 mg kg(-1), orally). The treatment was performed for 4 weeks, beginning on the fifth week after one intraperitoneal injection of STZ (65 mg kg(-1)). in the untreated model group, increased blood glucose, decreased plasma insulin level and an impaired renal function were observed. There was an altered redox system shown by an increased malondialdehyde and decreased activity of glutathione peroxidase and superoxide dismutase in the renal cortex. An enhanced inducible nitric oxide synthetase, total nitric oxide synthase and constitutive nitric oxide synthase and a declined nitric oxide were found. An increased extracellular matrix was indicated by an abnormality of MMP-2 and MMP-9 activities and an increase in hydroxyproline. An up-regulated ET-1 level and increased mRNA expression of endothelin-converting enzyme, preproET-1 and ETA receptor were presented in the affected renal cortex, but no change in ETB receptor mRNA. The LW was most effective in reversing these changes in diabetic rats and was as effective as aminoguanidine. The benefits of the extracts in relieving the abnormalities in early diabetic nephropathy are likely to be mediated by suppression of the renal ET-ROS system and escalating the activity of MMPs.
Addresses: Zhejiang Univ, Coll Pharmaceut Sci, Inst Chinese Herb Med, Hangzhou 310058, Zhejiang, Peoples R China; Dahe Clique, Ctr Med Sci Anal, Hangzhou 310053, Zhejiang, Peoples R China
Reprint Address: Wu, LM, Zhejiang Univ, Coll Pharmaceut Sci, Inst Chinese Herb Med, Hangzhou 310058, Zhejiang, Peoples R China.
E-mail Address: wulimao@zju.edu.cn
Cited Reference Count: 41
Times Cited: 2
Publisher: PHARMACEUTICAL PRESS-ROYAL PHARMACEUTICAL SOC GREAT BRITIAN
Publisher Address: 1 LAMBETH HIGH ST, LONDON SE1 7JN, ENGLAND
ISSN: 0022-3573
DOI: 10.1211/jpp.59.9.0015
29-char Source Abbrev.: J PHARM PHARMACOL
ISO Source Abbrev.: J. Pharm. Pharmacol.
Source Item Page Count: 9
Subject Category: Pharmacology & Pharmacy
ISI Document Delivery No.: 217TQ

Record 11 of 11
Author(s): He, HB
Title: The concept of good in ancient Greek literature
Source: FOREIGN LITERATURE STUDIES, (4): 121-+ AUG 2005
Language: Chinese
Document Type: Article
Author Keywords: ancient Greek literature; good; happiness; action; excellence
Abstract: Good is much emphasized in ancient Greek literature, with quite different, criteria from the Chinese ones. Their concept of good is closely connected with happiness, so good people are never ashamed of talking about their own interest: They pursue happiness as part of good. Good is a kind of dynamic function rather than motionless personal disposition; therefore, it can only be demonstrated in action. It is related to such noble qualities as courage, wisdom, power; and is characterized by excellence. However, it can be easily turned into the opposite of good if it is too enthusiastically practiced.
Addresses: Zhejiang Univ, Coll Foreign Languages, Dept English, Hangzhou, Peoples R China
Reprint Address: He, HB, Zhejiang Univ, Coll Foreign Languages, Dept English, Hangzhou, Peoples R China.
Cited Reference Count: 9
Times Cited: 0
Publisher: CENTRAL CHINA NORMAL UNIVERSITY
Publisher Address: 152 LUOYU RD,, WUHAN, 430079, PEOPLES R CHINA
ISSN: 1003-7519
29-char Source Abbrev.: FOREIGN LIT STUD
ISO Source Abbrev.: Foreign Lit. Stud.
Source Item Page Count: 5
Subject Category: Literature
ISI Document Delivery No.: 960RI