http://www.pnas.org/cgi/reprint/0712365105v1
浏览了一下，
1 文中没有提到“复方黄黛片”的名字，而是说一种“雄黄-青黛复方”(Realgar-Indigo naturalis formula，RIF)。相关的两篇参考文献有复方黄黛片。RIF有三种有效成分分别简称A、T、I。就文章本身来说，declare no conflict of interest并无不妥。
2 这篇文章用相当的篇幅证明了药效，而不光是引用参考文献。文中有五幅图，图一是小鼠的在体实验，图二是临床实验，药物诱导了白血病细胞的分化。
3 文中没有提到“君臣佐使”、“阴阳”等中医术语，但在讨论部分的观点和思路与新闻中宣传的基本一致。摘取几段：
Interestingly, TCM has advocated combinatory therapeutic strategies for >2,500 years. Based on the symptoms and characteristics of patients and guided by the theories of TCM, formulae are designed to contain a combination of different kinds of plants or minerals to improve clinical efficacy. One example is RIF, whose efficacies in treating APL have been well established recently (12, 13).
These results clearly show that components of RIF exert effects of mutual reinforcement. However, ATI does not show an intensified adverse effect in the APL murine model, as revealed by change in body weight, consistent with the safety of RIF observed in the clinic. These observations are in agreementwith the
rationality of the formula: mutual reinforcement of the compounds and reduction of adverse effects.
A large body of evidence indicates that PML-RAR is the causative oncoprotein of APL. Interestingly, A, which exhibits the strongest therapeutic effects in the murine APL model, has also been shown to be the principal agent of RIF in targeting PML-RAR. Furthermore, the TI combination enhances A-induced
ubiquitination and degradation of PML-RAR, augmenting the effects of A. Thus, the RIF formula, although designed by TCM doctors in the premolecular era of APL, proves its rationale by modern biochemical analysis.
Maintenance of normal cell cycle progression requires a balance of positive and negative regulators. The effects of ATI on cell cycle distribution are quite interesting, in that...This phenomenon not only suggests that ATI might trigger protein modification but also indicates that formulae might exert therapeutic effects through mechanisms beyond each component.
Finally, it is worth pointing out that, in the principle of designing a formula in TCM, some adjuvant components should be considered to facilitate the delivery of the principal element to the disease site in the body. It may be an interesting observation in this work that...
最后还提到了系统生物学。
This study may be considered a useful pilot trial in exploring the value of traditional formulae on a larger scale and in helping to bridge Western and the Eastern medicines in the era of systems biology.