他引的两篇文献我只能读到一篇,强调的是三聚氰胺和三聚氰酸单独给老鼠服用没问题,混起来就出问题。
SD rats were given upt to 100 mg/kg ammeline or
ammelide alone, a mixture of melamine and cyanuric acid (400/400 mg/kg/day), or a
mixture of all four compounds (400 mg/kg/day melamine, 40 mg/kg/day of the others).
Neither ammeline nor ammelide alone produced any renal effects, but the mixtures
produced significant renal damage and crystals in nephrons. HPLC-MS/MS confirmed
the presence of melamine and cyanuric acid in the kidney. Infrared microspectroscopy
on individual crystals from rat or cat (donated material from a veterinary clinic) kidneys
confirmed that they were melamine-cyanuric acid co-crystals. Crystals from
contaminated gluten produced comparable spectra. These results establish the causal
link between the contaminated gluten and the adverse effects and provide a mechanistic
explanation for how two apparently innocuous compounds could have adverse effects in
combination, i.e., by forming an insoluble precipitate in renal tubules leading to
progressive tubular blockage and degeneration.