the satellites are in orbits high above the Earth, where the curvature of spacetime due to the Earth's mass is less than it is at the Earth's surface. A prediction of General Relativity is that clocks closer to a massive object will seem to tick more slowly than those located further away. As such, when viewed from the surface of the Earth, the clocks on the satellites appear to be ticking faster than identical clocks on the ground. A calculation using General Relativity predicts that the clocks in each GPS satellite should get ahead of ground-based clocks by 45 microseconds per day.

From http://www.astronomy.ohio-state.edu/~pogge/Ast162/Unit5/gps.html