I really don't have much time to deal with a person like you and all the snob fans of yours. Please read the following ref and do some further search.
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Binding and transepithelial transport of immunoglobulins by intestinal M cells: demonstration using monoclonal IgA antibodies against enteric viral proteins.Weltzin R, Lucia-Jandris P, Michetti P, Fields BN, Kraehenbuhl JP, Neutra MR.
Department of Anatomy and Cellular Biology, Harvard University Medical School, Boston, Massachusetts 02115.
M cells of intestinal epithelia overlying lymphoid follicles endocytose luminal macromolecules and microorganisms and deliver them to underlying lymphoid tissue. The effect of luminal secretory IgA antibodies on adherence and transepithelial transport of antigens and microorganisms by M cells is unknown. We have studied the interaction of monoclonal IgA antibodies directed against specific enteric viruses, or the hapten trinitrophenyl (TNP), with M cells. To produce monospecific IgA antibodies against mouse mammary tumor virus (MMTV) and reovirus type 1, Peyer's patch cells from mucosally immunized mice were fused with myeloma cells, generating hybridomas that secreted virus-specific IgA antibodies in monomeric and polymeric forms. One of two anti-MMTV IgA antibodies specifically bound the viral surface glycoprotein gp52, and 3 of 10 antireovirus IgA antibodies immunoprecipitated sigma 3 and mu lc surface proteins. 35S-labeled IgA antibodies injected intravenously into rats were recovered in bile as higher molecular weight species, suggesting that secretory component had been added on passage through the liver. Radiolabeled or colloidal gold-conjugated mouse IgA was injected into mouse, rat, and rabbit intestinal loops containing Peyer's patches. Light microscopic autoradiography and EM showed that all IgA antibodies (antivirus or anti-TNP) bound to M cell luminal membranes and were transported in vesicles across M cells. IgA-gold binding was inhibited by excess unlabeled IgA, indicating that binding was specific. IgG-gold also adhered to M cells and excess unlabeled IgG inhibited IgA-gold binding; thus binding was not isotype-specific. Immune complexes consisting of monoclonal anti-TNP IgA and TNP-ferritin adhered selectively to M cell membranes, while TNP-ferritin alone did not. These results suggest that selective adherence of luminal antibody to M cells may facilitate delivery of virus-antibody complexes to mucosal lymphoid tissue, enhancing subsequent secretory immune responses or facilitating viral invasion.
PMID: 2541137 [pubmed - indexed for medline]
Related LinksSecretory immunoglobulin A antibodies against the sigma1 outer capsid protein of reovirus type 1 Lang prevent infection of mouse Peyer's patches. [j virol. 2004] PMID: 14694126 Selective adherence of IgA to murine Peyer's patch M cells: evidence for a novel IgA receptor. [j immunol. 2002] PMID: 12165508 Role of immunoglobulin A in protection against reovirus entry into Murine Peyer's patches. [j virol. 2001] PMID: 11602727 Mucin-related epitopes distinguish M cells and enterocytes in rabbit appendix and Peyer's patches. [infect immun. 1999] PMID: 9864237 Regulation of mucosal IgA production in vitro by autoreactive immunoregulatory T cells from murine Peyer's patches. [cell immunol. 1988] PMID: 2898979 See all Related Articles...
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I know you have a damaged ego. Comparing yourself to those "没学过多少生物医学基础课的中国"MD" might help your shaky self-esteem survive all your failures in your professional career, but it can't change the fact that you have neither medical training nor experience in medical research. You are not even a scientist any more. ".....对这位“医学科学专业人士”的牛烘烘的发问，参见拙文《以“蛋白”的名义》一文中有关分泌型IgA的段落。劝这位“医学科学专业人士”好好去补补医学基础课，不要
丢人现眼....."! You refered to yourself as if you were the greatest authority in the field,and your writing the most authoritive literature on this topic. Don't you feel it funny?
BTW, I have to tell you that I am an asistant professor in a medical school of a top American university. I know it is really stupid for people to make statement like this when talking about science. But you force people to deal with your snobishness by making you take your own medicine.