And deserve intervention. The 28% of prevalence is either overblown or waterw down its clinical significance to selected cases. It makes your application actually harder, because majority of these people never feel it is a problem and never seek medical help. I also know that some cases are very severe and it can last for days. It can disrupt sleep and daily functions. If you are able to identify how many people actually went to a doctor for help, it will help with your application. Limit your application to the right population.