balb/c



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送交者: trus 于 2006-4-07, 14:54:58:

回答: 请教肿瘤专家:BALB/c,C3H 和 C57BI/6是野生鼠? 由 lijun 于 2006-4-07, 14:27:40:

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Dr. Halsey J. Bagg, while at Memorial Hospital in New York, obtained albino (white coat with pink eyes) breeding stock from a mouse dealer in Ohio in 1913. In 1920 some of these mice were obtained from Dr. Bagg by Dr. C.C. Little and Dr. E.C. MacDowell at the Carnegie Institution of Washington in Cold Spring Harbor, New York. At Cold Spring Harbor the mice were inbred by MacDowell and by 1927 they were at F12 (MacDowell, 1927).

According to Potter (1985) "H.J. Muller, then at the University of Texas, acquired some of these mice from MacDowell, and when George Snell came to work with him in 1913 Snell acquired the colony (personal communication from George Snell to H.C. Morse, III). In 1935 Snell moved to The Jackson Laboratory and took the Bagg albinos with him. They were then at F26".

In 1935 Dr. Snell sent BALB/c breeders to Drs. Walter E. Heston and Howard B. Andervont at the National Institutes of health (NIH). The Andervont subline was incorporated into NIH main colonies in 1951. Dr. Snell added the "c" to the strain name to indicate that the genotype at the "color" locus was c/c. Thus the name of the strain was established as BALB/c. The strain name, originally Balb/c, was capitalized as a result of action by the Committee on Standardized Nomenclature for Inbred Strain of Mice.





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