送交者: 桂铭 于 2006-4-07, 01:49:16:
回答: 答“红旗飘飘”:我找到一份很有意思的文章 由 桂铭 于 2006-4-07, 01:23:38:
Importantly, an autologous vaccine encoding murine gp100 failed to generate tumor-protective immunity in this model system. The mechanism responsible for the greater immunogenicity of the human version of gp100 became apparent when mice were immunized with recombinant vaccinia virus containing minigenes encoding either human gp10025-33 or murine gp10025-33 peptide epitopes. Although the human and murine gp10025-33 epitopes were homologous and conformed to the predicted H-2Db antigen binding motif, differences in three NH2-terminal amino acids resulted in a 2-log increase in the ability of the human peptide to stabilize "empty" H-2Db antigens on RMA-S cells and a 3-log increase in triggering IFN- release by T cells compared with the murine peptide (10).
Xiang, R., et al. PNAS, 2000; 97: 5492-5497