试用黄连解毒汤



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送交者: laokang 于 2006-3-24, 08:03:08:

回答: 急问跨国医疗协议有关事项 由 天真 于 2006-3-23, 22:36:44:

The Effect of Oren-gedoku-to on Experimental Colitis in Rats

Authors: Zhou H.1; Mineshita S.1

Source: Journal of Pharmacy and Pharmacology, Volume 51, Number 9, 1 September 1999, pp. 1065-1074(10)

Publisher:Pharmaceutical Press


Abstract:

In Japan and China, Oren-gedoku-to (a complex mixture of ingredients derived from plants) has been used as a herbal medicine in the treatment of inflammatory and ulcerative diseases. In other countries salicylazosulfapyridine has been used to treat inflammatory bowel disease. In this study, we have compared the effect of Oren-gedoku-to with salicylazosulfapyridine on trinitrobenzene–sulphonic acid-induced colonic damage in rats, a model representative of ulcerative colitis and Crohn’s disease in man.

Oren-gedoku-to was administered orally for one or two weeks over a range of doses. Tissue damage scores, body weight, spleen weight, colon wet weight and colon wall thickness were measured, and colonic tissue levels of interleukin-8 (IL-8), leukotriene B4 (LTB4), prostaglandin E2 (PGE2), and myeloperoxidase activity were examined.

The results indicated that Oren-gedoku-to was effective in the treatment of inflammatory bowel disease in the rat model. Histological observation showed a quicker healing process of the lesions, and a reduction of inflammatory cell infiltration following administration of Oren-gedoku-to.

The precise mechanism of action for Oren-gedoku-to is still unclear; however, the reduction of IL-8, LTB4, and PGE2 observed suggests that the mechanism may be different from salicylazosulfapyridine (which has no effect on IL-8). There may be a potential benefit in offering combination therapy for the treatment of inflammatory bowel disease.

这个实验做的是动物,但是黄连解毒汤在日本门诊属于常规药物,70%以上的医生都在使用(不是中医)。这个实验可以看作为临床结果寻求基础上的论据。




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