Please don't say something without basic knowledge!



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送交者: Godfather 于 2006-3-20, 14:22:16:

回答: 有了现代医学,还用古人的医学观就是秦人的不对了. 由 antilier 于 2006-3-19, 20:21:49:

If you don't know something, nobody would blame you!

附子 is the roots of Acontium bcarmichaeli. According to modern studies on chemistry, pharmacology and toxicology, 生附子causes strong cardiac toxicity that results in human death. The reason for such toxicity was due to the presence of approximately 0.01% of an alkaloid called aconitine, [20-ethyl-1,6,16-trimethoxy-4-(methoxymethyl)- 8-acetate 14-benzoate-aconitane-3,8,13,14,15-pentol], and the LD50 for aconitine by s.c. is 0.295mg/kg in mice. After cooking and boiling 生附子 and drying, it’s called 熟附子 which the content of alkaloids, especially aconitine, decreases by 2000-4000 fold depending on the processes, harvest time and place of the plant. The strong cardiac effects disappeared after such heat processing just because aconitine was decomposed by hydrolysis of the benzoyl group to aconine, [20-ethyl-1,6,16-trimethoxy-4-(methoxymethyl)-aconitane-3,8,13,14,15-pentol]. LD50 for aconine increases to 3.516g/kg by i.v. in mice. Such actual chemical transformation from the processing has been known only since 1960s. 附子 has been prescribed in the complex prescriptions in Chinese medical practice for thousands years. In all cases, the doctors would tell the patients to use either熟附子 or boiling生附子. Obviously, it has been known for thousands years that 生附子 cannot be directly used as a medicine. What’s the beauty of this is that our ancients already knew how to properly use plant medicines in an adequate way before any modern scientific discovery. That’s only one of many examples in Zhong Yi Yao. Therefore, why should we get rid of such valuable knowledge and tools? Why do we have to use any drugs with clear molecular mechanisms? Besides, for most of the western (modern) medicines, their actual and complete mechanisms of actions are still unclear as well. Then, should we wait for the scientific advances before taking any medications??? Just simply ridiculous based on common sense!





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