Title: The effect of herbal medicine Toki-shakuyaku-san on blood pressure in an Nomega-nitro-L-arginine methyl ester-induced pre-eclampsia rat model during pregnancy and the postpartum period.
Journal: Journal of pharmacological sciences 98(3):255-62 (2005).
At the end of the paper the authors said:
“TS contains very many types of ingredients; therefore elucidation of the ingredient(s) and mechanism(s) responsible for the anti-hypertensive effect requires a wide range of view points and the performance of extensive phytochemical analyses in the future."
"Elucidation of the mechanism of action of TS is necessary to obtain an efficient treatment protocol for this drug.”
This means CHEMICAL analysis on TS and refining the formular are absolutely necessary before TS-containing/dereived drugs to be given to human patients.