Dr. de Grey's view sounds radical, but still very much to the point


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送交者: Wood 于 2006-10-27, 06:06:13:

回答: The Man Who Would Murder Death 由 insight 于 2006-10-27, 02:19:27:

I am not a cell biologist or geneticist, and I am not interested in what he is doing. If you are interested, you should read more articles, like this one:

Title: The function of genomes in bioenergetic organelles

Journal: Philosophical Transactions of the Royal Society B: Biological Sciences

Issue: Volume 358, Number 1429 / January 29, 2003
Pages: 19 - 38
DOI: 10.1098/rstb.2002.1191


A section you might want to read:
(e) The principle of the selective value of redox
control

For each gene under redox control (§ 3d), it is selectively advantageous for that gene to be retained and expressed only within the organelle. The twin selective advantages of redox control are likely to be energetic efficiency and the suppression of the harmful side effects of electron transport operating on the
wrong substrates. No direct experimental support for this principle is available, and, equally, there is no evidence against it. Allotopic mutants, in which genes have been experimentally relocated from organelles to the nucleus, have been produced in yeast, higher plants (Kanevski & Maliga 1994) and human cells (Manfredi et al. 2002) and are predicted by CORR to be poor adapters to environmental change. Some authors believe there is potential therapeutic value in allotopic transformation, moving mitochondrial genomes to the nucleus (Kanevski & Maliga 1994; de Grey 2000), and predict the possibility of r2 human cell lines in the foreseeable future (de Grey 2000). This principle also has implications for ageing and the evolution of separate sexes (Allen 1996) and possible consequences for development (Blackstone 1999, 2000,2001; Harvey et al. 2002) and somatic cloning in animals (Allen & Allen 1999).




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